(19)

(11)

EP 0 979 086 A2

(12)

(88) Date of publication A3: 12.08.1999 (43) Date of publication: 16.02.2000 Bulletin 2000/07 (21) Application number: 98919923.7 (22) Date of filing: 28.04.1998

(51) International Patent Classification (IPC)7: A61K 31/575 (86) International application number: PCT/US9808/463 (87) International publication number: WO 9848/784 (05.11.1998 Gazette 1998/44)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 28.04.1997 US 847616 (71) Applicant: THE UNIVERSITY OF BRITISH COLUMBIA Vancouver,British Columbia V6T 1Z1 (CA)	(72) Inventors: REINER, Peter, B. Vancouver, British Columbia V6R 1H8 (CA) LAM, Fred, Chiu-lai Vancouver, British Columbia V6P 3V2 (CA) (74) Representative: White, Martin Paul et al Fry Heath & Spence,The Old College,53 High Street Horley,Surrey RH6 7BN Horley,Surrey RH6 7BN (GB)