METHOD OF INDUCING VASODILATION AND TREATING PULMONARY HYPERTENSION USING ADENOVIRAL-MEDIATED TRANSFER OF THE NITRIC OXIDE SYNTHASE GENE - Patent 0979088

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EP 0 979 088 A1

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(43)	Date of publication:
	16.02.2000 Bulletin 2000/07

(21)	Application number: 97933529.6

(22)	Date of filing: 17.07.1997

(51)	International Patent Classification (IPC)⁷: A61K 31/70, C07H 21/04, C12N 15/12, C12N 15/63

(86)	International application number:
	PCT/US9712/510

(87)	International publication number:
	WO 9802/170 (22.01.1998 Gazette 1998/03)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

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Priority:

17.07.1996 US 21912 P

(71)	Applicants:
	THE GENERAL HOSPITAL CORPORATION Boston, MA 02110 (US) Leuven Research & Development V.Z.W. B-3000 Leuven (BE)

(72)	Inventors:
	JANSSENS, Stefan B-3001 Heverlee (BE) BLOCH, Kenneth, D. Brooklyn, MA 02146 (US) COLLEN, Désiré B-3020 Winksele (BE)

(74)	Representative: Sheard, Andrew Gregory et al
	Kilburn & Strode20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)

(54)	METHOD OF INDUCING VASODILATION AND TREATING PULMONARY HYPERTENSION USING ADENOVIRAL-MEDIATED TRANSFER OF THE NITRIC OXIDE SYNTHASE GENE