(19)

(11)

EP 0 979 238 A1

(12)

(43) Date of publication: 16.02.2000 Bulletin 2000/07 (21) Application number: 97941027.1 (22) Date of filing: 11.09.1997

(51) International Patent Classification (IPC)7: C07K 4/00, C07K 7/00, C07K 14/52, A61K 38/10, A61K 38/17, A61K 38/19 (86) International application number: PCT/US9716/062 (87) International publication number: WO 9839/357 (11.09.1998 Gazette 1998/36)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 05.03.1997 WO PCT/US97/04143 (71) Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Oakland,California 94612-3550 (US)	(72) Inventor: O'BRIEN, John S.,Univers.of California,San Diego La Jolla, CA 92093-1383 (US) (74) Representative: Groening, Hans Wilhelm, Dipl.-Ing.  BOEHMERT & BOEHMERTFranz-Joseph-Strasse 38 80801 München 80801 München (DE)