(19)

(11)

EP 0 980 257 A1

(12)

(43) Date of publication: 23.02.2000 Bulletin 2000/08 (21) Application number: 98919845.2 (22) Date of filing: 22.04.1998

(51) International Patent Classification (IPC)7: A61K 39/39, A61K 39/29, A61K 39/102, A61K 39/095 (86) International application number: PCT/US9808/146 (87) International publication number: WO 9850/071 (12.11.1998 Gazette 1998/45)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 01.05.1997 US 45262 P (71) Applicant: Chiron Corporation Emeryville,California 94608 (US)	(72) Inventors: GRANOFF, Dan, M. Emeryville, CA 94608 (US) GREER, Catherine, E. Emeryville, CA 94608 (US) VAN NEST, Gary, A. Emeryville, CA 94608 (US) (74) Representative: Hallybone, Huw George  CARPMAELS AND RANSFORD43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)