(19)
(11) EP 0 980 258 A1

(12)

(43) Date of publication:
23.02.2000 Bulletin 2000/08

(21) Application number: 98920669.3

(22) Date of filing: 12.05.1998
(51) International Patent Classification (IPC)7: A61K 39/395
(86) International application number:
PCT/GB9801/343
(87) International publication number:
WO 9851/344 (19.11.1998 Gazette 1998/46)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 12.05.1997 US 854881

(71) Applicant: THE KENNEDY INSTITUTE OF RHEUMATOLOGY
Hammersmith, London W6 8LH (GB)

(72) Inventors:
  • FELDMANN, Marc
    London N6 4QT (GB)
  • MAINI, Ravinder, Nath
    London SW13 9EW (GB)
  • PALEOLOG, Ewa, Maria
    London W5 3JR (GB)

(74) Representative: Harvey, David Gareth et al
Graham Watt & Co.Riverhead
SevenoaksKent TN13 2BN
SevenoaksKent TN13 2BN (GB)

   


(54) SUPPRESSION OF TUMOR NECROSIS FACTOR ALPHA AND VASCULAR ENDOTHELIAL GROWTH FACTOR IN THERAPY