(19)
(11) EP 0 980 372 A2

(12)

(88) Date of publication A3:
10.12.1998

(43) Date of publication:
23.02.2000 Bulletin 2000/08

(21) Application number: 98919330.5

(22) Date of filing: 29.04.1998
(51) International Patent Classification (IPC)7C07D 471/16, A61K 31/44
(86) International application number:
PCT/GB9801/239
(87) International publication number:
WO 9849/165 (05.11.1998 Gazette 1998/44)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 29.04.1997 GB 9708751

(71) Applicant: UNIVERSIDAD COMPLUTENSE DE MADRID
E-28040 Madrid (ES)

(72) Inventors:
  • FERNANDEZ PUENTES, José Luis
    E-24004 Leon (ES)
  • GARCIA GRAVALOS, Dolores
    E-28006 Madrid (ES)
  • AVENDANO LOPEZ, Carmen
    E-28036 Madrid (ES)
  • BLANCO CASTRO, Maria del Mar
    Madrid (ES)
  • MENENDEZ RAMOS, José Carlos
    E-28039 Madrid (ES)

(74) Representative: Ruffles, Graham Keith 
MARKS & CLERK,57-60 Lincoln's Inn Fields
London WC2A 3LS
London WC2A 3LS (GB)

   


(54) CYTOTOXIC COMPOUNDS: DERIVATIVES OF THE PYRIDO 2,3,4-$i(kl)] ACRIDINE RING SYSTEM