(19)

(11)

EP 0 981 368 A1

(12)

(43) Date of publication: 01.03.2000 Bulletin 2000/09 (21) Application number: 98920064.7 (22) Date of filing: 01.05.1998

(51) International Patent Classification (IPC)7: A61K 39/00, A61K 39/38, A61K 39/02, A61K 39/108, A23J 1/00, C07K 1/00, C07K 14/00, C07K 16/00, C07K 17/00 (86) International application number: PCT/US9808/768 (87) International publication number: WO 9850/068 (12.11.1998 Gazette 1998/45)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI NL PT SE (30) Priority: 02.05.1997 US 45511 P (71) Applicant: Department of the Army,U.S. Governament U.S. Army Medical & Research and Materiel Command Fort Detrick, MD 21702-5012 (US)	(72) Inventors: CASSELS, Frederick, J. Ellicott City, MD 21043 (US) PANNEL, Lewis, K. Silver Spring, MD 20902 (US) (74) Representative: Müller-Boré & PartnerPatentanwälte  Grafinger Strasse 2 81671 München 81671 München (DE)