(19)

(11)

EP 0 981 528 A1

(12)

(43) Date of publication: 01.03.2000 Bulletin 2000/09 (21) Application number: 98918764.6 (22) Date of filing: 28.04.1998

(51) International Patent Classification (IPC)7: C07D 495/04, A61K 31/435 (86) International application number: PCT/US9808/398 (87) International publication number: WO 9849/172 (05.11.1998 Gazette 1998/44)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 28.04.1997 US 44970 P (71) Applicant: THE UNIVERSITY OF VERMONT Burlington,Vermont 05405-0160 (US)	(72) Inventor: KRAPCHO, A., Paul Shelburne, VT 05482 (US) (74) Representative: Long, Giorgio et al Jacobacci & PeraniVia Senato, 8 20121 Milano 20121 Milano (IT)