(19)

(11)

EP 0 983 078 A1

(12)

(43) Date of publication: 08.03.2000 Bulletin 2000/10 (21) Application number: 98923812.6 (22) Date of filing: 27.05.1998

(51) International Patent Classification (IPC)7: A61K 38/00, A61K 39/395, A61K 48/00, C07H 21/04, C07K 14/435, C07K 14/705, C07K 16/00, C07K 16/18, C07K 16/28, C12N 15/01, C12N 15/11, C12N 15/12, C12N 15/63 (86) International application number: PCT/US9810/791 (87) International publication number: WO 9853/840 (03.12.1998 Gazette 1998/48)

(84) Designated Contracting States: BE CH DE DK FR GB IT LI NL (30) Priority: 27.05.1997 US 47572 P (71) Applicant: SMITHKLINE BEECHAM CORPORATION PhiladelphiaPennsylvania 19103 (US)	(72) Inventors: KIKLY, Kristine, Kay Linfield, PA 19468 (US) ERICKSON-MILLER, Connie, Lynn Exton, PA 19341 (US) (74) Representative: Crump, Julian Richard John  FJ Cleveland,40-43 Chancery Lane London WC2A 1JQ London WC2A 1JQ (GB)