(19)

(11)

EP 0 983 091 A1

(12)

(43) Date of publication: 08.03.2000 Bulletin 2000/10 (21) Application number: 98902573.9 (22) Date of filing: 16.01.1998

(51) International Patent Classification (IPC)7: A61K 45/05, A61K 38/00, A61K 38/19, C07K 1/00, C07K 14/52 (86) International application number: PCT/US9800/816 (87) International publication number: WO 9831/390 (23.07.1998 Gazette 1998/29)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE (30) Priority: 17.01.1997 US 35715 P 07.08.1997 US 54969 P 12.11.1997 US 65352 P (71) Applicant: ELI LILLY AND COMPANY Indianapolis, Indiana 46285 (US)	(72) Inventor: RINELLA, Joseph, V., Jr. Brownsburg, IN 46112 (US) (74) Representative: Denholm, Anna Marie et al Eli Lilly and Company Limited,Lilly Research Center,Erl Wood Manor Windlesham,Surrey GU20 6PH Windlesham,Surrey GU20 6PH (GB)