(19)
(11) EP 0 983 245 A1

(12)

(43) Date of publication:
08.03.2000 Bulletin 2000/10

(21) Application number: 98924263.1

(22) Date of filing: 28.04.1998
(51) International Patent Classification (IPC)7C07D 217/04, C07D 401/12, A61K 31/47
(86) International application number:
PCT/EP9802/584
(87) International publication number:
WO 9851/671 (19.11.1998 Gazette 1998/46)
(84) Designated Contracting States:
BE CH DE ES FR GB IT LI NL

(30) Priority: 09.05.1997 GB 9709303

(71) Applicant: SMITHKLINE BEECHAM PLC
Brentford,Middlesex TW8 9EP (GB)

(72) Inventors:
  • JOHNSON, Christopher, NorbertSmithKline Beecham
    Third AvenueHarlowEssex CM19 5AW (GB)
  • STEMP, GeoffreySmithKline Beecham Pharmaceuticals
    HarlowEssex CM19 5AW (GB)

(74) Representative: Garrett, Michael et al
SmithKline Beecham,Corporate Intellectual Property,Two New Horizons Court
Brentford,Middlesex TW8 9EP
Brentford,Middlesex TW8 9EP (GB)

   


(54) SUBSTITUTED TETRAHYDROISOQUINOLINE DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS