(19)

(11)

EP 0 983 296 A1

(12)

(43) Date of publication: 08.03.2000 Bulletin 2000/10 (21) Application number: 98918515.2 (22) Date of filing: 16.04.1998

(51) International Patent Classification (IPC)7: C07K 1/00, C07K 14/00, C07K 16/00, C07K 17/00, A61K 38/24, A61K 38/27, A23J 1/00, C12P 21/06, C12N 5/00, C12N 15/00, G01N 33/00 (86) International application number: PCT/US9807/996 (87) International publication number: WO 9846/622 (22.10.1998 Gazette 1998/42)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 17.04.1997 US 44007 P 21.05.1997 US 859988 (71) Applicant: WASHINGTON UNIVERSITY St. Louis, MO 63130 (US)	(72) Inventors: MILBRANDT, Jeffrey, D. St. Louis, MO 63105 (US) JOHNSON, Eugene, M., Jr. St. Louis, MO 63146 (US) BALOH, Robert, H. St. Louis, MO 63108 (US) (74) Representative: Brasnett, Adrian Hugh et al Mewburn EllisYork House23 Kingsway London WC2B 6HP London WC2B 6HP (GB)