(19)

(11)

EP 0 983 349 A1

(12)

(43) Date of publication: 08.03.2000 Bulletin 2000/10 (21) Application number: 98922963.8 (22) Date of filing: 26.05.1998

(51) International Patent Classification (IPC)7: C12N 15/10, C12N 15/12, C07K 1/04, C12N 15/62, C12Q 1/68, C07K 14/47, A61K 48/00 (86) International application number: PCT/GB9801/510 (87) International publication number: WO 9853/057 (26.11.1998 Gazette 1998/47)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 23.05.1997 GB 9710809 (71) Applicant: Gendaq Limited Mill Hill,London NW7 1AD (GB)	(72) Inventors: CHOO, YenMRC Laboratory of Molecular Biology Cambridge CB2 2QH (GB) KLUG, AaronMRC Laboratory of Molecular Biology Cambridge CB2 2QH (GB) ISALAN, Mark London SW14 8EA (GB) (74) Representative: Maschio, Antonio  D Young & Co,21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)