(19)

(11)

EP 0 983 354 A2

(12)

(88) Date of publication A3: 07.01.1999 (43) Date of publication: 08.03.2000 Bulletin 2000/10 (21) Application number: 98918805.7 (22) Date of filing: 27.04.1998

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/71, A61K 38/17, C07K 16/28 (86) International application number: PCT/US9808/486 (87) International publication number: WO 9854/213 (03.12.1998 Gazette 1998/48)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 30.05.1997 US 866354 (71) Applicant: AMGEN INC. Thousand Oaks, CA 91320-1789 (US)	(72) Inventors: FOX, Gary, M. Newbury Park, CA 91320 (US) JING, Shuqian Thousand Oaks, CA 91362 (US) WEN, Duanzhi Thousand Oaks, CA 91360 (US) (74) Representative: Richardson, Kate et al Forrester & Boehmert,Franz-Joseph Strasse 38 80801 München 80801 München (DE)