(19)
(11) EP 0 983 382 A1

(12)

(43) Date of publication:
08.03.2000 Bulletin 2000/10

(21) Application number: 98913083.6

(22) Date of filing: 23.03.1998
(51) International Patent Classification (IPC)7C12Q 1/68, C07H 21/04, G01N 33/53, A61K 48/00, A61K 31/56, C07K 16/28
(86) International application number:
PCT/US9805/789
(87) International publication number:
WO 9842/872 (01.10.1998 Gazette 1998/39)
(84) Designated Contracting States:
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 24.03.1997 US 41449 P

(71) Applicant: Spectra Biomedical
Burlingame, CA 94010 (US)

(72) Inventor:
  • PEROUTKA, Stephen, J.
    Hillsborough, CA 94010 (US)

(74) Representative: Cornish, Kristina Victoria Joy et al
Kilburn & Strode,20 Red Lion Street
London WC1R 4PJ
London WC1R 4PJ (GB)

   


(54) ESTROGEN AND THE MENTAL STATE: MOLECULAR VARIATIONS WITHIN THE ESTROGEN RECEPTOR GENE MODULATE CLINICAL SUSCEPTIBILITY TO DEPRESSION