(19)

(11)

EP 0 985 149 A1

(12)

(43) Date of publication: 15.03.2000 Bulletin 2000/11 (21) Application number: 98926115.1 (22) Date of filing: 29.05.1998

(51) International Patent Classification (IPC)7: G01N 33/50, A61K 38/18 (86) International application number: PCT/US9810/909 (87) International publication number: WO 9854/572 (03.12.1998 Gazette 1998/48)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 30.05.1997 US 866827 30.05.1997 US 48062 P 30.05.1997 US 48063 P (71) Applicant: CREATIVE BIOMOLECULES, INC. Hopkinton, MA 01748 (US)	(72) Inventors: SAMPATH, Kuber, T. Holliston, MA 01746 (US) COHEN, Charles, M. Weston, MA 02193 (US) (74) Representative: Schlich, George William et al Mathys & Squire100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)