(19)

(11)

EP 0 986 369 A1

(12)

(43) Date of publication: 22.03.2000 Bulletin 2000/12 (21) Application number: 98924470.2 (22) Date of filing: 28.05.1998

(51) International Patent Classification (IPC)7: A61K 7/48 (86) International application number: PCT/GB9801/568 (87) International publication number: WO 9855/088 (10.12.1998 Gazette 1998/49)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 07.06.1997 GB 9711786 (71) Applicant: IMPERIAL CHEMICAL INDUSTRIES PLC London SW1P 3JF (GB)	(72) Inventors: TAELMAN, Marie, Claire, Leona, Hilda B-9790 Wortegem-Petegem (BE) DEDEREN, Christian, Joseph B-3078 Meerbeek (BE) STICKDORN, Katrin B-1150 Brussels (BE) (74) Representative: Humphries, Martyn et al ICI Group Intellectual Property,P.O. Box 90 Wilton,Middlesbrough,Cleveland TS90 8JE Wilton,Middlesbrough,Cleveland TS90 8JE (GB)