(19)

(11)

EP 0 986 385 A1

(12)

(43) Date of publication: 22.03.2000 Bulletin 2000/12 (21) Application number: 98925129.3 (22) Date of filing: 01.06.1998

(51) International Patent Classification (IPC)7: A61K 31/40, A61K 31/44, C07D 213/73, C07D 407/06 (86) International application number: PCT/US9811/207 (87) International publication number: WO 9855/116 (10.12.1998 Gazette 1998/49)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 05.06.1997 US 48739 P 05.06.1997 US 48634 P 18.09.1997 GB 9719841 09.01.1998 GB 9800450 (71) Applicant: Merck & Co., Inc. RahwayNew Jersey 07065-0900 (US)	(72) Inventors: GOULET, Mark Rahway, NJ 07065 (US) UJJAINWALLA, Feroze Rahway, NJ 07065 (US) WALSH, Thomas, F. Rahway, NJ 07065 (US) WYVRATT, Matthew, J., Jr. Rahway, NJ 07065 (US) (74) Representative: Horgan, James Michael Frederic et al Merck & Co., Inc.,Terlings Park,Eastwick Road Harlow,Essex CM20 2QR Harlow,Essex CM20 2QR (GB)