(19)

(11)

EP 0 986 398 A1

(12)

(43) Date of publication: 22.03.2000 Bulletin 2000/12 (21) Application number: 98908558.4 (22) Date of filing: 25.02.1998

(51) International Patent Classification (IPC)7: A61K 39/00, A61K 39/395, C07K 14/705, C07K 16/28, C12N 15/12 (86) International application number: PCT/US9802/913 (87) International publication number: WO 9836/771 (27.08.1998 Gazette 1998/34)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 25.02.1997 US 806147 (71) Applicant: UNIVERSITY OF VIRGINIA PATENTS FOUNDATION Charlottesville,Virginia 22903 (US)	(72) Inventors: HERR, John, C. Charlottesville, VA 22908 (US) NAABY-HANSEN, Soren Charlottesville, VA 22908 (US) FLICKINGER, Charles, J. Charlottesville, VA 22908 (US) (74) Representative: Mager, Knut  c/o Schering Aktiengesellschaft 13342 Berlin 13342 Berlin (DE)