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EP 0 986 550 A1

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(43) Date of publication: 22.03.2000 Bulletin 2000/12 (21) Application number: 98926170.6 (22) Date of filing: 01.06.1998

(51) International Patent Classification (IPC)7: C07D 277/20, C07D 401/14, C07D 409/14, C07D 417/14, A61K 31/425, A61K 31/44 (86) International application number: PCT/US9811/203 (87) International publication number: WO 9855/470 (10.12.1998 Gazette 1998/49)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 05.06.1997 US 48639 P 05.06.1997 US 48742 P 11.09.1997 GB 9719386 11.09.1997 GB 9719387 (71) Applicant: MERCK & CO., INC. Rahway, New Jersey 07065 (US)

(72) Inventors: GOULET, Mark Rahway, NJ 07065 (US) UJJAINWALLA, Feroze Rahway, NJ 07065 (US) WALSH, Thomas, F. Rahway, NJ 07065 (US) WYVRATT, Matthew, J., Jr. Rahway, NJ 07065 (US) YOUNG, Jonathan, R. Rahway, NJ 07065 (US) CHU, Lin Rahway, NJ 07065 (US) (74) Representative: Horgan, James Michael Frederic et al Merck & Co., Inc.,Terlings Park,Eastwick Road Harlow,Essex CM20 2QR Harlow,Essex CM20 2QR (GB)