(19)

(11)

EP 0 986 553 A1

(12)

(43) Date of publication: 22.03.2000 Bulletin 2000/12 (21) Application number: 98902841.0 (22) Date of filing: 26.01.1998

(51) International Patent Classification (IPC)7: C07D 401/12, A61K 31/505 (86) International application number: PCT/US9801/429 (87) International publication number: WO 9833/791 (06.08.1998 Gazette 1998/31)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 04.02.1997 US 37183 P 26.06.1997 US 50893 P (71) Applicant: Bristol-Myers Squibb Company Wallingford, CT 06492-7660 (US)	(72) Inventors: BRUCE, Marc, A. Wallingford, CT 06492 (US) POINDEXTER, Graham, S. Old Saybrook, CT 06475 (US) JOHNSON, Graham Madison, CT 06443 (US) (74) Representative: Bentz, Jean-Paul et al Cabinet Weinstein,56 A, rue du Faubourg Saint-Honoré 75008 Paris 75008 Paris (FR)