(19)

(11)

EP 0 986 649 A1

(12)

(43) Date of publication: 22.03.2000 Bulletin 2000/12 (21) Application number: 98925826.4 (22) Date of filing: 04.06.1998

(51) International Patent Classification (IPC)7: C12N 15/86, C12N 5/16, C12M 3/00 (86) International application number: PCT/GB9801/626 (87) International publication number: WO 9855/640 (10.12.1998 Gazette 1998/49)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 04.06.1997 GB 9711578 (71) Applicant: Oxford Biomedica (UK) Limited Oxford 0X4 4GA (GB)	(72) Inventors: KINGSMAN, Alan, John Islip,Oxon OX5 2SF (GB) JONES, Ian, Martin Oxford OX2 8DY (GB) (74) Representative: Harding, Charles Thomas et al D. Young & Co.21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)