(19)

(11)

EP 0 988 024 A1

(12)

(43) Date of publication: 29.03.2000 Bulletin 2000/13 (21) Application number: 98918739.8 (22) Date of filing: 28.04.1998

(51) International Patent Classification (IPC)7: A61K 7/48 (86) International application number: PCT/US9808/356 (87) International publication number: WO 9848/777 (05.11.1998 Gazette 1998/44)

(84) Designated Contracting States: DE DK ES FR GB IE IT NL (30) Priority: 30.04.1997 GB 9708820 (71) Applicants: Sharp, Frederick Robert Milveron, Somerset T4A 1LD (GB) Von Krosigk, James Richard San Antonio, TX 78250 (US)	(72) Inventors: Sharp, Frederick Robert Milveron, Somerset T4A 1LD (GB) Von Krosigk, James Richard San Antonio, TX 78250 (US) (74) Representative: Johnson, Terence Leslie  Edward Evans & Co.,Clifford's Inn,Fetter Lane London EC4A 1BX London EC4A 1BX (GB)