(19)

(11)

EP 0 988 052 A2

(12)

(88) Date of publication A3: 14.05.1999 (43) Date of publication: 29.03.2000 Bulletin 2000/13 (21) Application number: 98929369.1 (22) Date of filing: 22.05.1998

(51) International Patent Classification (IPC)7: A61K 39/165, A61K 39/145, A61K 9/127, A61K 48/00 (86) International application number: PCT/EP9803/050 (87) International publication number: WO 9852/603 (26.11.1998 Gazette 1998/47)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 23.05.1997 EP 97108390 (71) Applicant: SCHWEIZ. SERUM- & IMPFINSTITUTBERN CH-3001 Bern (CH)	(72) Inventors: CUSI, Maria, Grazia I-53100 Siena (IT) GLÜCK, Reinhard CH-3095 Bern-Spiegel (CH) WÄLTI, Ernst CH-3053 Münchenbuchsee (CH) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)