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<ep-patent-document id="EP98929555B8W1" file="98929555.xml" lang="en" country="EP" doc-number="0988059" kind="B8" correction-code="W1" date-publ="20060301" status="c" dtd-version="ep-patent-document-v1-0">
<SDOBI lang="en"><B000><eptags><B001EP>ATBECHDEDKESFRGBGRITLILUNLSEMCPTIE......FI....CY................................</B001EP><B003EP>*</B003EP><B005EP>J</B005EP><B007EP>DIM360 (Ver 1.5  21 Nov 2005) -  2999001/0</B007EP></eptags></B000><B100><B110>0988059</B110><B120><B121>CORRECTED EUROPEAN PATENT SPECIFICATION</B121></B120><B130>B8</B130><B132EP>B1</B132EP><B140><date>20060301</date></B140><B150><B151>W1</B151><B153>73</B153><B155><B1551>de</B1551><B1552>Bibliographie</B1552><B1551>en</B1551><B1552>Bibliography</B1552><B1551>fr</B1551><B1552>Bibliographie</B1552></B155></B150><B190>EP</B190></B100><B200><B210>98929555.5</B210><B220><date>19980615</date></B220><B240><B241><date>19991203</date></B241><B242><date>20020918</date></B242></B240><B250>en</B250><B251EP>en</B251EP><B260>en</B260></B200><B300><B310>9712370</B310><B320><date>19970614</date></B320><B330><ctry>GB</ctry></B330></B300><B400><B405><date>20060301</date><bnum>200609</bnum></B405><B430><date>20000329</date><bnum>200013</bnum></B430><B450><date>20051207</date><bnum>200549</bnum></B450><B452EP><date>20050317</date></B452EP><B480><date>20060301</date><bnum>200609</bnum></B480></B400><B500><B510EP><classification-ipcr sequence="1"><text>A61K  47/48        19900101AFI20050303BHEP        </text></classification-ipcr><classification-ipcr sequence="2"><text>A61P  35/00        20000101ALI20050303BHEP        </text></classification-ipcr><classification-ipcr sequence="3"><text>A61K  38/44        19950101ALI20050303BHEP        </text></classification-ipcr><classification-ipcr sequence="4"><text>A61K  31/4422      20000101ALI20050303BHEP        </text></classification-ipcr></B510EP><B540><B541>de</B541><B542>MENSCHLICHE CHINON REDUKTASE KONJUGATE FÜR ADEPT UND GDEPT</B542><B541>en</B541><B542>HUMAN QUINONE REDUCTASE 2 CONJUGATES FOR ADEPT AND GDEPT</B542><B541>fr</B541><B542>CONJUGES DE QUINONE-REDUCTASE HUMAIN POUR ADEPT ET GDEPT</B542></B540><B560><B561><text>WO-A-93/08288</text></B561><B561><text>WO-A-95/12678</text></B561><B561><text>WO-A-97/07097</text></B561><B561><text>WO-A-97/24143</text></B561><B561><text>WO-A-98/22577</text></B561><B562><text>KNOX R J ET AL: "THE BIOACTIVATION OF CB 1954 AND ITS USE AS A PRODRUG IN ANTIBODY-DIRECTED ENZYME PRODRUG THERAPY (ADEPT)" CANCER AND METASTASIS REVIEWS, vol. 12, no. 2, 1993, pages 195-212, XP000618513 cited in the application</text></B562><B562><text>FRIEDLOS F ET AL: "METABOLISM OF NADPH BY BLOOD COMPONENTS RELEVANCE TO BIOREDUCTIVELY ACTIVATED PRODRUGS IN A TARGETED ENZYME THERAPY SYSTEM" BIOCHEM PHARMACOL, vol. 44, no. 4, 1992, pages 631-635, XP000618526 cited in the application</text></B562><B562><text>WU K ET AL: "Catalytic properties of NAD(P)H:quinone oxidoreductase-2 (NQO2), a dihydronicotinamide riboside dependent oxidoreductase." ARCH BIOCHEM BIOPHYS, NOV 15 1997, 347 (2) P221-8, XP002080156 UNITED STATES</text></B562><B562><text>MELTON, R. G. ET AL: "Antibody-directed enzyme prodrug therapy (ADEPT). Review article" DRUGS OF THE FUTURE, vol. 21, no. 2, 1996, pages 167-184, XP002080157</text></B562><B562><text>SHERWOOD R F: "ADVANCED DRUG DELIVERY REVIEWS: ENZYME PRODRUG THERAPY" ADVANCED DRUG DELIVERY REVIEWS, vol. 22, 1996, pages 269-288, XP002064128</text></B562><B562><text>GREEN N. K. ET AL: "Sensitization of colorectal and pancreatic cancer cell lines to the prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) by retroviral transduction and expression of the E. coli nitroreductase gene" CANCER GENE THERAPY, vol. 4, no. 4, August 1997, pages 229-238, XP002092056</text></B562><B562><text>DRABEK D. ET AL: "The expression of bacterial nitroreductase in transgenic mice results in specific cell killing by the prodrug CB1954" GENE THERAPY, vol. 4, no. 2, February 1997, pages 93-100, XP002092057</text></B562></B560></B500><B600><B620EP><parent><cdoc><dnum><anum>04076964.8</anum><pnum>1468698</pnum></dnum><date>20040707</date></cdoc></parent></B620EP></B600><B700><B720><B721><snm>BURKE, Philip, John</snm><adr><str>45 Elliscombe Road,
Charlton</str><city>London SE7 7PF</city><ctry>GB</ctry></adr></B721><B721><snm>KNOX, Richard, John</snm><adr><str>21 Cypress Court,
Cheam Road</str><city>Sutton,
Surrey SM1 2SU</city><ctry>GB</ctry></adr></B721></B720><B730><B731><snm>Protherics Molecular Design Limited</snm><iid>07210350</iid><irf>ENZM/P19133EP</irf><adr><str>The Health Business and Technical Park</str><city>Runcorn
Cheshire WA7 4QF</city><ctry>GB</ctry></adr></B731></B730><B740><B741><snm>Miles, John Stephen</snm><iid>00086141</iid><adr><str>Eric Potter Clarkson LLP 
Park View House 
58 The Ropewalk</str><city>Nottingham NG1 5DD</city><ctry>GB</ctry></adr></B741></B740></B700><B800><B840><ctry>AT</ctry><ctry>BE</ctry><ctry>CH</ctry><ctry>CY</ctry><ctry>DE</ctry><ctry>DK</ctry><ctry>ES</ctry><ctry>FI</ctry><ctry>FR</ctry><ctry>GB</ctry><ctry>GR</ctry><ctry>IE</ctry><ctry>IT</ctry><ctry>LI</ctry><ctry>LU</ctry><ctry>MC</ctry><ctry>NL</ctry><ctry>PT</ctry><ctry>SE</ctry></B840><B860><B861><dnum><anum>GB1998001731</anum></dnum><date>19980615</date></B861><B862>en</B862></B860><B870><B871><dnum><pnum>WO1998057662</pnum></dnum><date>19981223</date><bnum>199851</bnum></B871></B870><B880><date>19990812</date><bnum>000000</bnum></B880></B800></SDOBI>
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