(19)

(11)

EP 0 988 371 A1

(12)

(43) Date of publication: 29.03.2000 Bulletin 2000/13 (21) Application number: 98926471.8 (22) Date of filing: 10.06.1998

(51) International Patent Classification (IPC)7: C12N 1/21 (86) International application number: PCT/US9811/932 (87) International publication number: WO 9856/892 (17.12.1998 Gazette 1998/50)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 11.06.1997 US 52991 P (71) Applicant: Human Genome Sciences, Inc. Rockville, MD 20850 (US)	(72) Inventors: NI, Jian Rockville, MD 20853 (US) YU, Guo-Liang San Mateo, CA 94403 (US) FAN, Ping Gaithersburg, MD 20878 (US) GENTZ, Reiner, L. Rockville, MD 20850 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)