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(11)

EP 0 988 398 A1

(12)

(43) Date of publication: 29.03.2000 Bulletin 2000/13 (21) Application number: 98923705.2 (22) Date of filing: 21.05.1998

(51) International Patent Classification (IPC)7: C12Q 1/68, C12P 19/34, C07H 21/02, C07H 21/04 (86) International application number: PCT/US9810/561 (87) International publication number: WO 9853/103 (26.11.1998 Gazette 1998/47)

(84) Designated Contracting States: DE FR GB IT (30) Priority: 21.05.1997 US 859998 31.03.1998 US 53375 (71) Applicant: Clontech Laboratories, Inc. Palo Alto, CA 94303-4230 (US)	(72) Inventors: CHENCHIK, Alex Palo Alto, CA 94306 (US) JOKHADZE, George Mountain View, CA 94041 (US) BIBILASHVILLI, Robert Moscow, 121170 (RU) (74) Representative: Brasnett, Adrian Hugh et al Mewburn EllisYork House23 Kingsway London WC2B 6HP London WC2B 6HP (GB)