(19)
(11) EP 0 989 981 A1

(12)

(43) Date of publication:
05.04.2000 Bulletin 2000/14

(21) Application number: 98932719.2

(22) Date of filing: 15.06.1998
(51) International Patent Classification (IPC)7C07D 401/04, C07D 221/16, A61K 31/55, A61K 31/435
(86) International application number:
PCT/US9811/509
(87) International publication number:
WO 9857/950 (23.12.1998 Gazette 1998/51)
(84) Designated Contracting States:
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
Designated Extension States:
LT LV RO

(30) Priority: 17.06.1997 US 877052

(71) Applicant: SCHERING CORPORATION
KenilworthNew Jersey 07033 (US)

(72) Inventors:
  • AFONSO, Adriano
    West Caldwell, NJ 07006 (US)
  • KELLY, Joseph, M.
    Parlin, NJ 08859 (US)
  • WEINSTEIN, Jay
    Upper Montclair, NJ 07043 (US)
  • WOLIN, Ronald, L.
    Bedminister, NJ 07921 (US)
  • ROSENBLUM, Stuart, B.
    West Orange, NJ 07052 (US)

(74) Representative: Ritter, Stephen David et al
Mathys & Squire100 Grays Inn Road
London WC1X 8AL
London WC1X 8AL (GB)

   


(54) NOVEL PHENYL-SUBSTITUTED TRICYCLIC INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE