(19)

(11)

EP 0 989 997 A2

(12)

(88) Date of publication A3: 04.03.1999 (43) Date of publication: 05.04.2000 Bulletin 2000/14 (21) Application number: 98932162.5 (22) Date of filing: 09.06.1998

(51) International Patent Classification (IPC)7: C07K 14/00 (86) International application number: PCT/EP9803/662 (87) International publication number: WO 9856/811 (17.12.1998 Gazette 1998/50)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 12.06.1997 ES 9701292 (71) Applicant: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS E-28006 Madrid (ES)	(72) Inventors: GUTIERREZ-ARMENTA, Crisanto E-28049 Madrid (ES) QI, Xie E-28049 Madrid (ES) SANZ-BURGOS, Andrés E-28049 Madrid (ES) (74) Representative: Dolan, Anthony Patrick  BTG International Ltd.,10 Fleet Place,Limeburner Lane London EC4M 7SB London EC4M 7SB (GB)