(19)

(11)

EP 0 990 022 A1

(12)

(43) Date of publication: 05.04.2000 Bulletin 2000/14 (21) Application number: 98931511.4 (22) Date of filing: 23.06.1998

(51) International Patent Classification (IPC)7: C12N 1/00 (86) International application number: PCT/US9813/041 (87) International publication number: WO 9859/250 (30.12.1998 Gazette 1998/52)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 24.06.1997 US 50667 P (71) Applicant: Human Genome Sciences, Inc. Rockville, MD 20850 (US)	(72) Inventor: FRASER, Claire, M. Potomac, MD 20854 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)