(19)

(11)

EP 0 990 046 A2

(12)

(88) Date of publication A3: 18.03.1999 (43) Date of publication: 05.04.2000 Bulletin 2000/14 (21) Application number: 98932288.8 (22) Date of filing: 25.06.1998

(51) International Patent Classification (IPC)7: C12Q 1/68 (86) International application number: PCT/GB9801/862 (87) International publication number: WO 9900/516 (07.01.1999 Gazette 1999/01)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 25.06.1997 GB 9713469 (71) Applicant: MEDICAL RESEARCH COUNCIL London W1N 4AL (GB)	(72) Inventors: LOVELL-BADGE, Robin Mill Hill,London NW7 1AA (GB) PEVNY, Laryssa, H. Mill Hill,London NW7 1AA (GB) SMITH, Austin,Centre for Genome Research East Mains Road,Edinburgh EH9 3WQ (GB) (74) Representative: Maschio, Antonio et al D Young & Co,21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)