(19)

(11)

EP 0 990 051 A1

(12)

(43) Date of publication: 05.04.2000 Bulletin 2000/14 (21) Application number: 98945752.8 (22) Date of filing: 07.07.1998

(51) International Patent Classification (IPC)7: C12Q 1/68, G01N 33/536 (86) International application number: PCT/US9814/082 (87) International publication number: WO 9902/733 (21.01.1999 Gazette 1999/03)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 07.07.1997 US 51780 P 07.07.1997 US 51781 P (71) Applicant: Florida State University Tallahassee, FL 32306-2763 (US)	(72) Inventors: MAKOWSKI, Lee Arlington, VA 22207 (US) MAKOWSKI, Diane, R. Arlington, VA 22207 (US) SANGANEE, Hitesh, J. Tallahassee, FL 32306 (US) (74) Representative: Nargolwalla, Cyra  Cabinet Plasseraud84, rue d'Amsterdam 75440 Paris Cedex 09 75440 Paris Cedex 09 (FR)