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(11)

EP 0 991 321 A1

(12)

(43) Date of publication: 12.04.2000 Bulletin 2000/15 (21) Application number: 98906135.3 (22) Date of filing: 05.02.1998

(51) International Patent Classification (IPC)7: A01N 63/00, A01N 43/04, A61K 48/00, C12N 9/00, C12N 5/00, C12N 5/06, C12N 5/08, C12N 5/10 (86) International application number: PCT/US9802/141 (87) International publication number: WO 9833/387 (06.08.1998 Gazette 1998/31)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 05.02.1997 US 796663 (71) Applicant: THE GENERAL HOSPITAL CORPORATION Boston, MA 02110 (US)	(72) Inventors: IACOMINI, John, J. Somerville, MA 02143 (US) DER SIMONIAN, Harout Wellesley, MA 02181 (US) SACHS, David, H. Newton, MA 02166 (US) (74) Representative: Ruffles, Graham Keith et al MARKS & CLERK,57-60 Lincoln's Inn Fields London WC2A 3LS London WC2A 3LS (GB)