(19)

(11)

EP 0 991 418 A1

(12)

(43) Date of publication: 12.04.2000 Bulletin 2000/15 (21) Application number: 98908554.3 (22) Date of filing: 24.02.1998

(51) International Patent Classification (IPC)7: A61K 38/00, A61K 38/16, A61K 38/22, A61K 38/19, A61K 39/00 (86) International application number: PCT/US9802/907 (87) International publication number: WO 9836/762 (27.08.1998 Gazette 1998/34)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE (30) Priority: 25.02.1997 US 806046 (71) Applicant: ELI LILLY AND COMPANY Indianapolis, Indiana 46285 (US)	(72) Inventors: HEIMAN, Mark, L. Indianapolis, IN 46250 (US) CRAFT, Libbey, S. Indianapolis, IN 46236 (US) (74) Representative: Denholm, Anna Marie  Eli Lilly and Company Limited,Lilly Research Center,Erl Wood Manor Windlesham,Surrey GU20 6PH Windlesham,Surrey GU20 6PH (GB)