(19)

(11)

EP 0 991 422 A1

(12)

(43) Date of publication: 12.04.2000 Bulletin 2000/15 (21) Application number: 97920411.2 (22) Date of filing: 17.04.1997

(51) International Patent Classification (IPC)7: A61K 38/18 (86) International application number: PCT/US9706/309 (87) International publication number: WO 9738/708 (23.10.1997 Gazette 1997/45)

(84) Designated Contracting States: DE FR GB (30) Priority: 18.04.1996 US 15560 P (71) Applicant: THE GENERAL HOSPITAL CORPORATION Boston, MA 02114 (US)	(72) Inventors: GOETINCK, Paul, F. Boston, MA 02216 (US) SONG, HeeKyung Cambridge, MA 02139 (US) WANG, Yuying Boston, MA 02115 (US) (74) Representative: Ruffles, Graham Keith  MARKS & CLERK,57-60 Lincoln's Inn Fields London WC2A 3LS London WC2A 3LS (GB)