DEUTERATED and undeuterated CYCLOSPORINE ANALOGS AND THEIR USE AS IMMUNOMODULATING AGENTS

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EP 0 991 660 B8

(12)	CORRECTED EUROPEAN PATENT SPECIFICATION
	Note: Bibliography reflects the latest situation

(15)	Correction information:
	Corrected version no 1 (W1 B1)

(48)	Corrigendum issued on:
	05.04.2006 Bulletin 2006/14

(45)	Mention of the grant of the patent:
	28.12.2005 Bulletin 2005/52

(21)	Application number: 98947718.7

(22)	Date of filing: 08.10.1998

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International Patent Classification (IPC):

C07K 7/64^(1985.01)

A61K 38/13^(1995.01)

(86)	International application number:
	PCT/IB1998/001693

(87)	International publication number:
	WO 1999/018120 (15.04.1999 Gazette 1999/15)

(54)	DEUTERATED and undeuterated CYCLOSPORINE ANALOGS AND THEIR USE AS IMMUNOMODULATING AGENTS DEUTERIERtE und undeuterierte CYCLOSPORIN-ANALOGA UND IHRE VERWENDUNG ALS IMMUNMODULIERENDE AGENtIEN ANALOGUES DE CYCLOSPORINE DEUTERES et non-deuteres ET LEUR UTILISATION COMME IMMUNOMODULATEURS

(84)	Designated Contracting States:
	AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
	Designated Extension States:
	RO

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Priority:

08.10.1997 US 61360 P

(43)	Date of publication of application:
	12.04.2000 Bulletin 2000/15

(60)	Divisional application:
	05024216.3

(73)	Proprietor: ISOTECHNIKA,INC.
	Edmonton, Alberta T6G 2CB (CA)

(72)	Inventors:
	NAICKER, S., Selvaraj Edmonton, Alberta T6J 3J4 (CA) YATSCOFF, Randall, W. Edmonton, Alberta T6R 2B7 (CA) FOSTER, Robert, T. Edmonton, Alberta T6J 1X9 (CA)

(74)	Representative: Nash, David Allan
	HASELTINE LAKE, Redcliff Quay 120 Redcliff Street Bristol BS1 6HU Bristol BS1 6HU (GB)

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References cited: :

EP-A- 0 283 801
EP-A- 0 577 544

EP-A- 0 373 260
WO-A-95/26325

D. SEEBACH ET AL.: "MODIFICATION OF CYCLOSPORIN A (CS): GENERATION OF AN ENOLATE AT THESARCOSINE RESIDUE AND REACTIONS WITH ELECTROPHILES" HELVETICA CHIMICA ACTA, vol. 76, 1993, pages 1564-1590, XP002022424
H. KOBEL ET AL.: "Contribution to knowledge of the biosynthesis of cyclosporin A" EXPERIENTIA, vol. 39, 1983, pages 873-876, XP002090783
EBERLE M K ET AL: "Modifications of the MeBmt Side Chain of Cyclosporin A" BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 5, no. 15, 3 August 1995, page 1725-1728 XP004135415


	Remarks:
	The file contains technical information submitted after the application was filed and not included in this specification

Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).