(19)

(11)

EP 0 993 300 A1

(12)

(43) Date of publication: 19.04.2000 Bulletin 2000/16 (21) Application number: 98923316.8 (22) Date of filing: 30.04.1998

(51) International Patent Classification (IPC)7: A61K 31/40, A61K 31/41, A61K 31/44, A61K 31/445, A61K 31/535, C07D 401/10, C07D 409/10, C07D 409/12, C07D 413/10 (86) International application number: PCT/US9808/700 (87) International publication number: WO 9848/798 (05.11.1998 Gazette 1998/44)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE (30) Priority: 30.04.1997 US 45173 P (71) Applicant: ELI LILLY AND COMPANY Indianapolis, Indiana 46285 (US)

(72) Inventors: CHIRGADZE, Nickolay Yuri Carmel, IN 46032 (US) HARPER, Richard, Waltz Indianapolis, IN 46240 (US) KOHN, Todd, Jonathan Fishers, IN 46038 (US) LIN, Ho-Shen Indianapolis, IN 46217 (US) MCCOWAN, Jefferson, R. Indianapolis, IN 46208 (US) PALKOWITZ, Alan, David Carmel, IN 46032 (US) SALL, Daniel, Jon Greenwood, IN 46142 (US) SMITH, Gerald, Floyd Indianapolis, IN 46217 (US) TAKEUCHI, Kumiko Indianapolis, IN 46268 (US) WILEY, Michael, Robert Indianapolis, IN 46268 (US) ZHANG, Minsheng Warren, NJ 07059 (US) (74) Representative: Hudson, Christopher Mark et al Eli Lilly and Company Limited,Lilly Research Centre,Erl Wood Manor WindleshamSurrey GU20 6PH WindleshamSurrey GU20 6PH (GB)