(19)

(11)

EP 0 993 449 A1

(12)

(43) Date of publication: 19.04.2000 Bulletin 2000/16 (21) Application number: 98932276.3 (22) Date of filing: 17.06.1998

(51) International Patent Classification (IPC)7: C07D 215/26, A61K 31/47 (86) International application number: PCT/GB9801/770 (87) International publication number: WO 9857/936 (23.12.1998 Gazette 1998/51)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 17.06.1997 GB 9712761 (71) Applicant: Darwin Discovery Limited Cambridge CB4 4WE (GB)	(72) Inventors: DYKE, Hazel, Joan Milton RoadCambridge CB4 4WE (GB) MONTANA, John, Gary Milton RoadCambridge CB4 4WE (GB) HAUGHAN, Alan, Findlay Milton RoadCambridge CB4 4WE (GB) SABIN, Verity, Margaret Milton RoadCambridge CB4 4WE (GB) (74) Representative: Perry, Robert Edward  GILL JENNINGS & EVERYBroadgate House7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)