(19)

(11)

EP 0 994 708 A1

(12)

(43) Date of publication: 26.04.2000 Bulletin 2000/17 (21) Application number: 98926173.0 (22) Date of filing: 01.06.1998

(51) International Patent Classification (IPC)7: A61K 31/44, C07D 213/73, C07D 407/06 (86) International application number: PCT/US9811/208 (87) International publication number: WO 9855/123 (10.12.1998 Gazette 1998/49)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 05.06.1997 US 48638 P 05.06.1997 US 48642 P 18.09.1997 GB 9719840 09.01.1998 GB 9800454 (71) Applicant: MERCK & CO., INC. Rahway, New Jersey 07065 (US)	(72) Inventors: GOULET, Mark Rahway, NJ 07065 (US) WYVRATT, Matthew, J., Jr. Rahway, NJ 07065 (US) CHU, Lin Rahway, NJ 07065 (US) GIROTRA, Narindar, N. Rahway, NJ 07065 (US) LIN, Peter Rahway, NJ 07065 (US) (74) Representative: Horgan, James Michael Frederic et al Merck & Co., Inc.,Terlings Park,Eastwick Road Harlow,Essex CM20 2QR Harlow,Essex CM20 2QR (GB)