(19)
(11) EP 0 994 717 A1

(12)

(43) Date of publication:
26.04.2000 Bulletin 2000/17

(21) Application number: 98908452.0

(22) Date of filing: 26.01.1998
(51) International Patent Classification (IPC)7: A61K 35/30, A61K 38/00, A61K 38/28, A61K 31/495, A61K 31/50
(86) International application number:
PCT/US9801/648
(87) International publication number:
WO 9832/451 (30.07.1998 Gazette 1998/30)
(84) Designated Contracting States:
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 24.01.1997 US 36722 P

(71) Applicant: AUTOIMMUNE, INC.
Lexington, MA 02173 (US)

(72) Inventors:
  • WEINER, Howard, L.
    Brookline, MA 02193 (US)
  • AL-SABBAGH, Ahmad
    West Roxbury, MA 02132 (US)
  • NELSON, Patricia, A.
    Belmont, MA (US)

(74) Representative: Grünecker, Kinkeldey, Stockmair & SchwanhäusserAnwaltssozietät 
Maximilianstrasse 58
80538 München
80538 München (DE)

   


(54) TREATMENT OF AUTOIMMUNE DISEASE USING TOLERIZATION IN COMBINATION WITH METHOTREXATE