(19)
(11) EP 0 994 943 A2

(12)

(88) Date of publication A3:
14.05.1999

(43) Date of publication:
26.04.2000 Bulletin 2000/17

(21) Application number: 98937563.9

(22) Date of filing: 09.07.1998
(51) International Patent Classification (IPC)7C12N 9/00, C12N 15/00, C12N 15/52
(86) International application number:
PCT/EP9804/265
(87) International publication number:
WO 9902/659 (21.01.1999 Gazette 1999/03)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
RO SI

(30) Priority: 09.07.1997 GB 9714475

(71) Applicant: BIOCHEMIE GESELLSCHAFT M.B.H.
6250 Kundi (AT)

(72) Inventors:
  • SCHÖRGENDORFER, Kurt
    A-6322 Langkampfen (AT)
  • STEMPFER, Günther
    A-6330 Kufstein (AT)
  • HUSI, Holger
    Edinburgh EH9 1LG (GB)
  • WALKINSHAW, Malcolm, Douglas
    Edinburgh EH13 0JB (GB)

(74) Representative: Becker, Konrad et al
Novartis AGGeistiges Eigentum KonzernPatent- und Markenabteilung CHPostfach
4002 Basel
4002 Basel (CH)

   


(54) METHOD OF ALTERING THE DOMAINS OF CYCLOSPORIN SYNTHETASE TO GIVE A MODIFIED CYCLOSPORIN SYNTHETASE