(19)

(11)

EP 0 995 118 A1

(12)

(43) Date of publication: 26.04.2000 Bulletin 2000/17 (21) Application number: 98932418.1 (22) Date of filing: 10.07.1998

(51) International Patent Classification (IPC)7: G01N 33/50, C12Q 1/02 (86) International application number: PCT/GB9802/042 (87) International publication number: WO 9902/989 (21.01.1999 Gazette 1999/03)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 10.07.1997 GB 9714582 28.08.1997 GB 9718261 (71) Applicant: MEDICAL RESEARCH COUNCIL London W1N 4AL (GB)	(72) Inventors: FERSHT, AlanCambridge University Chemical Cambridge CB2 1EW (GB) CHATELLIER, JeanMRC Laboratory of Molecular Cambridge CB2 2QH (GB) (74) Representative: Maschio, Antonio  D Young & Co,21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)