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(11)

EP 0 996 708 A1

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(43) Date of publication: 03.05.2000 Bulletin 2000/18 (21) Application number: 98935611.8 (22) Date of filing: 10.07.1998

(51) International Patent Classification (IPC)7: C12N 5/00, C12N 15/00, C07H 21/04 (86) International application number: PCT/US9814/376 (87) International publication number: WO 9902/652 (21.01.1999 Gazette 1999/03)

(84) Designated Contracting States: BE DE FR GB NL (30) Priority: 11.07.1997 US 52324 P (71) Applicant: THE GENERAL HOSPITAL CORPORATION Boston, MA 02114 (US)	(72) Inventors: HART, Anne, C. Boston, MA 02129 (US) FABER, Peter Burlington, MA 01803 (US) MACDONALD, Marcy Lexington, MA 02173 (US) (74) Representative: Bösl, Raphael, Dr. rer. nat., Dipl.-Chem. et al Patent- und RechtsanwälteBardehle . Pagenberg . Dost . Altenburg . Geissler . IsenbruckGalileiplatz 1 81679 München 81679 München (DE)