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(11)

EP 0 998 280 A1

(12)

(43) Date of publication: 10.05.2000 Bulletin 2000/19 (21) Application number: 98924946.1 (22) Date of filing: 28.05.1998

(51) International Patent Classification (IPC)7: A61K 31/395, A61K 38/00, C07D 487/00, C07D 487/04 (86) International application number: PCT/US9810/867 (87) International publication number: WO 9853/813 (03.12.1998 Gazette 1998/48)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 29.05.1997 US 47946 P (71) Applicant: Incara Pharmaceuticals Corp. Cranbury, NJ 08512 (US)	(72) Inventors: CHAN, Tin, Yau Edison, NJ 08817 (US) SOFIA, Michael, J. Lawrenceville, NJ 08648 (US) (74) Representative: Luderschmidt, Schüler & Partner GbR  Patentanwälte,John-F.-Kennedy-Strasse 4 65189 Wiesbaden 65189 Wiesbaden (DE)