(19)

(11)

EP 0 998 563 A1

(12)

(43) Date of publication: 10.05.2000 Bulletin 2000/19 (21) Application number: 98936015.1 (22) Date of filing: 24.07.1998

(51) International Patent Classification (IPC)7: C12N 15/12, C12N 15/62, C07K 14/705, C07K 16/28, C12N 5/10, G01N 33/68 (86) International application number: PCT/US9815/493 (87) International publication number: WO 9905/276 (04.02.1999 Gazette 1999/05)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 25.07.1997 US 53715 P (71) Applicant: ZymoGenetics, Inc. Seattle, WA 98102 (US)	(72) Inventors: SHEPPARD, Paul, O. Redmond, WA 98053 (US) MOORE, Emma, E. Seattle, WA 98199 (US) (74) Representative: Schlich, George William et al Mathys & Squire100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)