METHODS OF PERFORMING HOMOLOGOUS RECOMBINATION BASED MODIFICATION OF NUCLEIC ACIDS IN RECOMBINATION DEFICIENT CELLS AND USE OF THE MODIFIED NUCLEIC ACIDS - Patent 0998574

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EP 0 998 574 A1

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(43)	Date of publication:
	10.05.2000 Bulletin 2000/19

(21)	Application number: 98930459.7

(22)	Date of filing: 23.06.1998

(51)	International Patent Classification (IPC)⁷: C12N 15/70, C12N 15/90, A01K 67/027

(86)	International application number:
	PCT/US9812/966

(87)	International publication number:
	WO 9859/060 (30.12.1998 Gazette 1998/52)

(84)	Designated Contracting States:
	AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
	Designated Extension States:
	AL LT LV MK RO SI

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Priority:

23.06.1997 US 880966
22.06.1998 US 102490

(71)	Applicant: THE ROCKEFELLER UNIVERSITY
	New YorkNew York 10021-6399 (US)

(72)	Inventors:
	HEINTZ, Nathaniel Pelham Manor, NY 10803 (US) MODEL, Peter New York, NY 10021 (US) YANG, Xiangdong, W. New York, NY 10021 (US)

(74)	Representative: Harrison Goddard Foote
	Belmont House,20 Wood Lane Leeds LS6 2AE Leeds LS6 2AE (GB)

(54)	METHODS OF PERFORMING HOMOLOGOUS RECOMBINATION BASED MODIFICATION OF NUCLEIC ACIDS IN RECOMBINATION DEFICIENT CELLS AND USE OF THE MODIFIED NUCLEIC ACIDS