(19)

(11)

EP 1 000 155 A1

(12)

(43) Date of publication: 17.05.2000 Bulletin 2000/20 (21) Application number: 98930905.9 (22) Date of filing: 19.06.1998

(51) International Patent Classification (IPC)7: C12N 15/31, C07K 14/33, C07K 16/12, C12N 1/21, C12N 15/62, G01N 33/569, A61K 39/08, A61K 39/40 (86) International application number: PCT/GB9801/805 (87) International publication number: WO 9859/053 (30.12.1998 Gazette 1998/52)

(84) Designated Contracting States: DE FR GB (30) Priority: 20.06.1997 GB 9713146 07.01.1998 GB 9800321 (71) Applicants: QUEEN MARY & WESTFIELD COLLEGE London E1 4NS (GB) IMPERIAL COLLEGE OF SCIENCE,TECHNOLOGY & MEDICINE London SW7 2AZ (GB)	(72) Inventors: WARD, Stephen, JohnQueen Mary & Westfield College London E1 4NS (GB) WREN, Brendan, WilliamQueen Mary & Westfield Col London E1 4NS (GB) DOUGAN, GordonImperial College of Science London SW7 2AZ (GB) DOUCE, Gill-Imperial College of Science London SW7 2AZ (GB) (74) Representative: Nachshen, Neil Jacob et al D Young & Co21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)