(19)

(11)

EP 1 000 357 A1

(12)

(43) Date of publication: 17.05.2000 Bulletin 2000/20 (21) Application number: 98934354.6 (22) Date of filing: 09.07.1998

(51) International Patent Classification (IPC)7: G01N 33/53, C07K 16/00, A61K 39/395 (86) International application number: PCT/US9814/216 (87) International publication number: WO 9902/991 (21.01.1999 Gazette 1999/03)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 10.07.1997 US 52132 P (71) Applicant: RESEARCH DEVELOPMENT FOUNDATION Carson CityNevada 89703 (US)	(72) Inventors: SANDERS, Robert Austin, TX 78726 (US) KLINE, Kimberly Austin, TX 78703 (US) (74) Representative: Wilkinson, Stephen John et al Stevens, Hewlett & Perkins1 St. Augustine's Place Bristol BS1 4UD Bristol BS1 4UD (GB)