(19)

(11)

EP 1 001 747 A1

(12)

(43) Date of publication: 24.05.2000 Bulletin 2000/21 (21) Application number: 98940262.3 (22) Date of filing: 05.08.1998

(51) International Patent Classification (IPC)7: A61K 9/00, A61K 47/00, A61K 31/35 (86) International application number: PCT/EP9804/972 (87) International publication number: WO 9907/341 (18.02.1999 Gazette 1999/07)

(84) Designated Contracting States: BE CH DE ES FR GB IT LI NL (30) Priority: 09.08.1997 GB 9716805 27.03.1998 GB 9806682 (71) Applicant: SMITHKLINE BEECHAM PLC Brentford,Middlesex TW8 9EP (GB)

(72) Inventors: HATTON, Anthony, GuySmithKline Beecham Pharmac. HarlowEssex CM19 5AW (GB) HILTON, Jane, ElizabethSmithKline Beecham Pharm. HarlowEssex CM19 5AW (GB) SCOTT, HughSmithKline Beecham Pharmaceuticals HarlowEssex CM19 5AW (GB) TALLON, Teresita, Regina, GeradineSmithKlineBee HHarlowEssex CM19 5AW (GB) (74) Representative: Connell, Anthony Christopher et al SmithKline Beecham plcCorporate Intellectual Property,Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)