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(11)

EP 1 001 764 A1

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(43) Date of publication: 24.05.2000 Bulletin 2000/21 (21) Application number: 98926122.7 (22) Date of filing: 29.05.1998

(51) International Patent Classification (IPC)7: A61K 31/395, A61K 31/40, A61K 31/41, A61K 31/415, A61K 31/425, A61K 31/435, A61K 31/44, A61K 31/445, A61K 31/47, A61K 31/495, A61K 31/535, C07D 205/02, C07D 209/04, C07D 209/14, C07D 209/30, C07D 217/12, C07D 235/02, C07D 233/64, C07D 241/02, C07D 257/04, C07D 265/30, C07D 275/02, C07D 277/02, C07D 277/08, C07D 295/08 (86) International application number: PCT/US9810/940 (87) International publication number: WO 9853/814 (03.12.1998 Gazette 1998/48)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 29.05.1997 US 48017 P 07.07.1997 GB 9714314 25.11.1997 US 66525 P 14.01.1998 GB 9800686 (71) Applicant: Merck & Co., Inc. (a New Jersey corp.) Rahway, N.J. 07065 (US)

(72) Inventors: DURETTE, Philippe, L. Rahway, NJ 07065 (US) HAGMANN, William, K. Rahway, NJ 07065 (US) MacCOSS, Malcolm Rahway, NJ 07065 (US) MILLS, Sander, G. Rahway, NJ 07065 (US) MUMFORD, Richard, A. Rahway, NJ 07065 (US) VAN RIPER, Gail, M. Rahway, NJ 07065 (US) SCHMIDT, Jack, A. Rahway, NJ 07065 (US) KEVIN, Nancy, J. Rahway, NJ 07065 (US) (74) Representative: Hiscock, Ian James et al European Patent Department,Merck & Co., Inc.,Terlings Park,Eastwick Road Harlow,Essex CM20 2QR Harlow,Essex CM20 2QR (GB)